㈠ 鐫姣涘為暱娑茬湡鐨勬湁鐢ㄥ悧錛熻╃潾姣涙洿鍔犵氦闀
鐫姣涘為暱娑插彲浠ュ彲浠ュ府鍔╃潾姣涙瘮杈冪煭鐨勫圭焊鐫姣涘彉寰楃氦闀匡紝鍚璧鋒潵闈炲父紲炲囷紝浣嗘槸寰堝氫漢瀵逛簬瀹冪殑鏁堟灉鍜屾寔緇鏃墮棿鎶辨湁瑙傛湜鍜岃川鐤戠殑鎬佸害銆備笅闈㈠氨鏉ヤ竴鎺㈢┒絝熷惂錛
鐫姣涘為暱娑茬湡鐨勬湁鐢ㄥ悧鍙鑳芥湁鐨勪漢瑙夊緱鐫姣涘為暱娑茶繖涓浜у搧騫朵笉闈犺氨錛屽彧鏄鍟嗗跺ｄ紶浜у搧鐨勪竴縐嶅櫛澶寸艦浜嗐備絾鍏跺疄鍙瑕佷綘涔扮殑鏄閭ｇ嶈川閲忓悎鏍肩殑鐫姣涘為暱娑茬殑璇濓紝閭ｄ箞鍏跺疄鐫姣涘為暱娑叉槸鐨勭『鏈夊府鍔╂垜浠澧為暱鐫姣涚殑浣滅敤鐨勩
涓鑸鏉ヨ寸潾姣涘為暱娑插垎涓轟袱縐嶏紝絎涓縐嶆槸甯鍔╂垜浠鍒烘縺姣涘彂鐢熼暱鐨勭潾姣涘為暱娑詫紝榪欑嶇潾姣涘為暱娑插畠鍙浠ュ府鍔╂垜浠鍒烘縺姣涘泭鐨勬椿鎬э紝淇冧嬌姣涘泭鐢熼暱鍑烘洿澶氱溂鐫姣涳紝鑰屼笖榪樺彲浠ュ府鍔╃幇鏈夌殑鐫姣涚戶緇鍙戣偛鐢熼暱錛屼粠鑰岃揪鍒頒竴涓澧為暱鐫姣涚殑鐩鐨勶紝騫朵笖榪樺彲浠ヨ╂垜浠鐨勭潾姣涘彉鐨勬洿鍔犵殑嫻撳瘑銆
鑰屽彟涓縐嶅氨鏄浠ユ粙鍏葷洰鐨勪負涓伙紝榪欎竴縐嶇潾姣涘為暱娑茬殑涓昏佺洰鐨勬槸緇欐垜浠鐜版湁鐨勭湁姣涙彁渚涜惀鍏伙紝鎴戜滑鐨勭潾姣涘傛灉鏈夎凍澶熺殑钀ュ吇鏉ュ惛鍙栫殑璇濓紝閭ｄ箞瀹冨氨鍙浠ユ洿濂界殑鐢熼暱銆
鐫姣涘為暱娑蹭粈涔堟椂鍊欑敤鏁堟灉濂
鐫姣涘垎涓烘瘺鏍瑰拰鎴戜滑鐪嬪緱瑙佺殑姣涙潌閮ㄥ垎錛岀敓闀垮懆鏈熶竴鑸閮藉湪涓涓鏈堝乏鍙籌紝涔嬪悗鐨3-5涓鏈堥兘澶勪簬浼戞㈢姸鎬侊紝鐫姣涙粙鍏繪恫瑕佸仛鐨勫伐浣滃垎涓轟袱閮ㄥ垎錛屼竴鏄婊嬫鼎姣涙牴錛屾敼鍠勬瘺鍙戠敓闀跨幆澧冿紝浣跨潾姣涘彉寰楁洿涓烘祿瀵;鍙︿竴涓鍒欐槸嬋媧誨凡緇忓勪簬浼戞㈡湡鐨勭潾姣涳紝璁╁畠鍙橀暱錛屽彉綺楋紝寤剁紦鑴辮惤鏃墮棿銆傛墍浠ワ紝婊嬪吇娑插彲浠ユ棭鏅氫嬌鐢錛岃屾渶濂界殑浣跨敤鏃墮棿鏄鏅氫笂銆
鐫姣涘為暱娑插師鐞
鐫姣涚殑鐢熼暱鏍規湰鍘熷洜鏄鐢變簬姣涘共銆佹瘺鍥婇噷杈癸紝鏈変簺鐢熷彂涓蹇冪殑騫茬粏鑳烇紝鑰屼綘鐜板湪鐪嬪埌鐨勭潾姣涘苟涓嶆槸鍏ㄩ儴閮藉勪簬鐢熼暱鏈熺殑錛屾湁浜涙瘺鍥婃槸澶勪簬浼戠湢鐘舵佺殑錛屽氨鏄鐫＄潃浜嗭紝闇瑕佽搗搴婂彨閱掓湇鍔★紝鑰岀潾姣涘為暱娑蹭細鍚鏈変竴浜涚墿璐錛屽埡嬋姣涘泭緇嗚優褰㈡垚緇勭粐淇冧嬌鐫姣涘姞蹇鐢熼暱錛屽彉寰楁瘮浠ュ墠鏇寸矖鏇村瘑鏇撮粦
鐫姣涘為暱娑插瓨鍦ㄥ壇浣滅敤
閭ｄ簺閫氳繃灝忔瘺鍒鳳紝鎶婇傞噺鐨勭敓闀挎恫鍒蜂竴鍒峰埛鍦ㄧ潾姣涚殑鏍歸儴灝變細韞韞韞鐨勯暱鐫姣涚殑鍟嗗搧鎬庝箞灝辮繖涔堢炲囧憿? 鎯寵佸紕鎳傜潾姣涘為暱娑叉湁浠涔堢炲囩殑錛屾渶閲嶈佺殑鏄瑕佺煡閬撶潾姣涚敓闀挎恫鐨勬椿鎬ф垚鍒嗘槸浠涔?
1.綾寵哄湴灝
綾寵哄湴灝旀槸鏈夊悕鐨勯檷琛鍘嬭嵂鐗╋紝鐢2%綾寵哄湴灝旀憾娑叉不鐤楃敺鎬ч泟嬋緔犳ц劚鍙戱紝鏁堟灉闈炲父鐨勬槑鏄撅紝鍙浠ュ炲姞姣涘彂鐨勭敓闀塊熷害錛屼漢浠灝辨兂鍒扮敤鍒扮潾姣涗笂鍘匯傚彲鏄榪欐牱鐨勪駭鍝佹湁寰堝己鐨勫壇浣滅敤錛屽彲鑳戒細寮曡搗鐫姣涗互澶栫殑閮ㄤ綅鐢熼暱姣涘彂錛岃佷笉涓嶈ュ紶姣涚殑鍦版柟闀挎瘺浜嗭紝閭ｅ氨灝村艾浜嗭紝鍛靛懙鍛點傜編鍥紽DA宸查氳繃浜2%鍜5%綾寵哄湴灝旀憾娑蹭負闈炲勬柟鑽錛屽墠鑰呯敺濂沖潎閫傜敤錛屽悗鑰呬粎閫傜敤浜庣敺鎬х背璇哄湴灝旀恫浼氬紩璧峰埡嬋鎬ф垨鍙樺簲鎬ф帴瑙︽ц繃鏁忓弽搴旓紝鎵浠ョ洰鍓嶅競闈涓婄殑鐫姣涘為暱娑插緢灝戝惈鏈夎繖鏍風殑鎴愬垎銆
2.姣旈┈鍓嶅垪緔
涓嬈″伓鐒剁殑鏈轟細錛屽尰鐢熶滑鍙戠幇浜嗚繖涓鎴愬垎錛屾湰鏉ユ槸鍦ㄦ不鐤楅潚鍏夌溂鐨(ps錛氶潚鍏夌溂寰堥毦娌葷枟鐨勩)錛屼篃鏈変竴瀹氱殑鏁堟灉錛屽彲浠ユ煇涓鍖葷敓鍙戠幇錛屾不鐤楃殑榪囩▼涓鐥呬漢鐨勭潾姣涘掓槸澧為暱浜嗭紝榪欎釜鍖葷敓灝卞洖瀹剁粰澶澶浣跨敤錛岀粨鏋滆╄嚜宸辯殑澶澶鏈変簡涓鍙岃糠浜虹殑鐪肩潧銆傝繖鏍鋒瘮椹鍓嶅垪緔犲氨琚榪愮敤鍒頒簡鐫姣涘為暱娑蹭腑錛屻備絾鏄涔熸湁涓瀹氱殑鍓浣滅敤錛岄暱鏃墮棿浣跨敤瀹規槗鍒烘縺緇撹啘錛岀敋鑷寵掕啘錛屽紩璧峰埡鐥涙劅錛岃掕啘婧冪枴絳夐棶棰橈紝闇瑕侀殢鏃舵敞鎰忎笉鑹鍙嶅簲銆
3.鐫姣涚敓闀胯偨
璇ユ垚鍒 鑲夎眴钄婚叞浜旇偨-17 Myristoyl Pentapeptide-17 錛岀幇鍦ㄤ綔涓哄寲濡嗗搧鏂板師鏂欐垚鍒嗭紝嬈х編鍦板尯宸茬粡騫挎硾搴旂敤錛屼絾鍥藉唴榪樻病鏈夎鏀跺綍鍦ㄣ婂凡浣跨敤鍖栧嗗搧鍘熸枡鍚嶇О鐩褰曘嬮噷 錛屽逛簬CFDA鏉ヨ達紝榪欐槸涓涓鏈夊緟鍟嗘Ψ鐨勬垚鍒嗐傚彟澶栵紝 姣涘彂鐢熼暱綾葷殑浜у搧灞炰簬鐗規畩鍖栧嗗搧錛岄渶瑕佺粡榪嘋FDA瀹℃壒鍙栧緱鐗硅瘉鎵嶈兘鐢熶駭閿鍞錛屾ｅ父鐨勭壒璇佸℃壒闇瑕佷竴騫村崐鏃墮棿 錛岃屼粖騫村勾鍒濈殑鐫姣涚敓闀誇駭鍝侊紝瀛曠潾緔犻洦鍚庢槬絎嬭埇鐨勫啋鍑烘潵錛屽嚑涓鏈堢殑鏃墮棿錛岄亶鍦板紑鑺憋紝涓涓鐨勭湡鐩稿楄礬錛屽ぇ瀹舵兂鎯沖氨鐭ラ亾浜嗐
浣跨敤10%鍚閲忕殑鐫姣涜偨錛2鍛ㄨ兘淇冭繘鐫姣涘炵矖澧為暱24%錛屽苟涓斾環鏍兼瘮杈冮備腑錛岃繕鑳界敤浜庝績榪涘ご鍙戠殑鐢熼暱銆傜浉瀵規槸鏈涓哄畨鍏ㄧ殑鎴愬垎浜嗐
4.鐢熼暱鍥犲瓙
涓嶅皯瀛曠潾緔犵殑璧勬枡瀹ｄ紶鏌愪簺鐢熼暱鍥犲瓙鍙浠ヤ績榪涚潾姣涚殑鐢熼暱錛岀劧騫跺嵉錛岀敱浜庣敓闀垮洜瀛愮殑緇撴瀯鐩稿硅緝澶嶆潅錛岃愮儹鎬у樊錛屾櫘閬嶅湪甯告俯涓7澶╁唴渚垮け鍘繪椿鎬э紝鍙鑳藉仛鎴愬喕騫茬矇浣跨敤錛屼笉澶閫傚悎鐫姣涚敓闀挎恫鍙婂瓡鐫緔犵殑浜у搧褰㈠紡鍜岃揣鏋跺懆鏈燂紝鎵浠ュ競鍦轟笂瀹ｄ紶娣誨姞浜嗚ユ垚鍒嗙殑瀛曠潾緔犱駭鍝侊紝鍩烘湰灞炰簬姒傚康鎬х殑娣誨姞(灝辨坊鍔犱簡0.000000000001%宸﹀彸)錛屼嬌鐢ㄨ繖綾繪垚鍒嗙殑瀛曠潾緔犲苟娌℃湁浠涔堟晥鏋溿 緇忚繃涓杞鎶戒笣鍓ヨ導浠ュ悗錛屾垜浠澶ц嚧鍙浠ョ煡閬擄紝鐫姣涚敓闀胯偨鏄鐩鍓嶇浉瀵規瘮杈冨畨鍏ㄦ湁鏁堢殑鐫姣涚敓闀跨殑瀛曠潾緔犳椿鎬ф垚鍒嗭紝鍙鎯滃按灝鐨勬槸錛岃ユ垚鍒嗚倝璞嗚敾閰頒簲鑲-17Myristoyl Pentapeptide-17錛岀幇鍦ㄤ綔涓哄寲濡嗗搧鏂板師鏂欐垚鍒嗘х編鍦板尯宸茬粡騫挎硾搴旂敤錛屼絾鍥藉唴榪樻病鏈夎鏀跺綍鍦ㄣ婂凡浣跨敤鍖栧嗗搧鍘熸枡鍚嶇О鐩褰曘嬮噷錛屽逛簬CFDA鏉ヨ達紝榪欐槸涓涓鏈夊緟鍟嗘Ψ鐨勬垚鍒嗐
浠婂勾騫村垵鐨勭潾姣涚敓闀誇駭鍝侊紝瀛曠潾緔犻洦鍚庢槬絎嬭埇鐨勫啋鍑烘潵錛屽嚑涓鏈堢殑鏃墮棿錛岄亶鍦板紑鑺憋紝涓涓鐨勭湡鐩稿楄礬錛屽ぇ瀹舵兂鎯沖氨鐭ラ亾浜嗐備嬌鐢ㄦ椂錛屾湁涓撶敤鐨勫皬鍒峰瓙鎶婂皯閲忕殑鐫姣涚敓闀挎恫鍒峰湪鐫姣涙牴閮ㄥ嵆鍙錛屼竴鑸涓嶄細瀵圭溂鐫涙湁涓嶈壇鐨勫獎鍝嶃 浣嗘槸綾寵哄湴灝斻佹瘮椹鍓嶅垪緔犳湁涓瀹氬埡嬋鎬э紝騫朵笖浼氶檷浣庣溂鍘嬨傛墍浠ヤ嬌鐢ㄥ悗涓ょ嶆垚鍒嗙殑浜у搧鏄鍙浠ョ殑錛屼竴縐嶆湁鏁堟灉鐨勭壒璇佷駭鍝侊紝涓縐嶆槸蹇冪悊浣滅敤鐨勪駭鍝併